Tuesday, March 27, 2018

Preventing Alzheimer's dementia with Ibuprofen

Researchers suggest that daily intake of nonsteroidal anti-inflammatory drugs like over the counter ibuprofen could prevent the onset of Alzheimer's disease. This research is led by Dr. Patrick McGeer and is published in the Journal of Alzheimer's Disease.

Alzheimer's dementia affects those diagnosed and their family along with a significant financial burden on the society. It is estimated around 47 million people worldwide are affected by this and is the fifth leading cause of death in those aged 65 and above. The Alzheimer's Association estimates that there are more than 5 million cases in the United States alone. The annual cost United States in 2017 is estimated to be around $259 billion and the projected for the costs go to 1.1 trillion by 2050.

According to the latest publication by Dr. Patrick McGeer diagnosis of people at risk of Alzheimer's disease is possible with positron-electron microscopy for AD senile plaques, blood or saliva analysis for the elevation of the amyloid-β protein fragment terminating at position 42, and cerebrospinal fluid analysis showing a decrease in the content of this protein. The publication also suggests prevention strategies like self-treatment by consumption of non-steroidal anti-inflammatory drugs, adhering to a Mediterranean diet, and consuming antioxidants such as quercitin which is contained in coffee.

Reference: Mcgeer, Patrick L., and Edith Mcgeer. "Conquering Alzheimer’s Disease by Self Treatment." Journal of Alzheimers Disease, 2018, 1-3. doi:10.3233/jad-179913.

Adapted from press release by IOS press.
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