Saturday, January 7, 2017

Tau protein as biomarker for predicting recovery time after concussion

Elevated levels of the brain protein tau following a sport-related concussion are associated with a longer recovery period and delayed return to play for athletes, according to a study published in Journal Neurology. The findings suggest that tau, which can be measured in the blood, may serve as a marker to help physicians determine an athlete's readiness to return to the game.

Brain. Credit: Ashton University.
A team led by Jessica Gill, R.N., Ph.D. of the National Institute of Nursing Research at the National Institutes of Health and Jeffrey Bazarian, M.D., M.P.H. of the University of Rochester Medical Center evaluated changes in tau in 46 Division I and III college athletes who experienced a concussion. Tau, which plays a role in the development of chronic traumatic encephalopathy or CTE, frontotemporal dementia and Alzheimer's disease was measured in preseason blood samples and again within 6 hours following concussion using an ultra-sensitive technology that allows researchers to detect single protein molecules.

The athletes - a mix of soccer, football, basketball, hockey and lacrosse players from the University of Rochester and Rochester Institute of Technology - were divided into two groups based on recovery time. Athletes in the "long return to play" group took more than 10 days to recover following concussion, while athletes in the "short return to play" group took less than 10 days to return to their sport.

Individuals in the long return to play group had higher levels of tau in their blood 6 hours after concussion compared to those in the short return to play group. Long return to play athletes also exhibited a jump in tau from preseason levels compared to their short return to play counterparts. Statistical analyses showed that higher blood tau concentrations 6 hours post-concussion consistently predicted that an athlete would take more than 10 days to resume play.

The study included both male and female athletes and showed that tau-related changes occurred in both genders across a variety of sports. The team found significant differences based on sex: women made up 61 percent of the long return to play group, but only 28 percent of the short return to play group. Bazarian says this isn't surprising; it's well established that females take longer to recover following concussion than males.

Bazarian and Gill acknowledge that the study is limited by its small size and that more research is needed to establish tau as a biomarker of concussion severity. Next steps include getting blood samples from athletes immediately following a concussion to see if the relationship between tau and return to play holds true on the sideline in the first few minutes following a head hit.

Citation: Gill,Jessica,  Kian Merchant-Borna, Andreas Jeromin,  Whitney Livingston, and Jeffrey Bazarian. Acute plasma tau relates to prolonged return to play after concussion. Neurology 2017. DOI: 10.1212/WNL.0000000000003587
Research funding: NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH/National Institute of Nursing Research.
Adapted from press release by The University of Rochester Medical Center.

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